Liang Shan, PhD

Dr. Liang Shan is an Assistant Professor in the Department of Medicine at Washington University in St. Louis. Dr. Shan is an expert on HIV latent reservoir, viral-specific CD8+ T cells, innate sensing of HIV, and humanized mouse model of HIV infection. His seminal work has advanced the understanding of priming CD8+ T cell responses for HIV reservoir clearance. Recently, his lab focuses on the role of the CARD8 inflammasome in HIV pathogenesis and cure. Dr. Shan has developed human cytokine knock-in mouse models named MISTRG-6-15, which supports robust reconstitution of human innate immune cells including monocytes, tissue macrophages, and NK cells, in addition to B and T lymphocytes. This humanized mouse model is key to the work proposed herein